Research at Leeds Beckett
Dr Andrew Paterson
About Dr Andrew Paterson
From a background in physiology and pharmacology, Andrew undertook a PhD examining mitochondria in models of disease and published journal articles identifying mitochondrial changes in models of prion disease and Rett Syndrome. He has an interest in the role of oxidative stress in disease states, and more recently, has collaborated with Professor Barry Parsons and others in a project examining the free radical induced fragmentation of hyaluronan.
Andrew currently uses cell culture approaches to investigate the effects of endogenous molecules and xenobiotics on cultured cell lines.
Current projects involve three main strands of investigation. Firstly the investigation of the cytotoxic properties of nanoparticles and mechanisms of toxicity on cultured cells, secondly the assessment of cytotoxicity of herbal preparations and phytochemicals which show promise as novel antimicrobials in collaboration with Dr Margarita Gomez Escalada, and thirdly the development of models to assess the attachment of pathogens to models of the human gastrointestinal tract.
BSc (Hons) Biomedical Sciences: Human Physiology and Genetics, Medical Physiology, Topics in Neuroscience, Project
BSc (Hons) Speech and Language Therapy: Anatomy and Physiology for SLT, Medical Disciplines
MSc Toxicological Sciences: Cellular Toxicology, Molecular Toxicology, Project
Potential impact of current work:
- Elucidation of mechanisms by which hyaluronan fragments under pro-oxidative conditions may suggest future therapeutic approaches used to treat or control inflammatory conditions affecting the joints.
- Assessing the toxicity of novel phytochemical antimicrobials can be used to indicate the potential of such agents in the treatment of infections and as such can be used to help direct future research effort in combating infectious diseases and antibiotic resistance.
- Development of methodologies to quantify bacterial attachment to models of the human gastrointestinal tract allows assessment of the effectiveness of agents in the prevention or control of such attachment thereby having implications towards the development of treatment and prevention strategies for diarrhoeal diseases.