Research at Leeds Beckett
The study of Biomedicine encompasses research into many aspects of medically-related technologies and practices. Biomedical research undertaken by staff and students involves the interdisciplinary study of many areas, including: analytical chemistry, electrochemistry, biomedical engineering, microbiology, xenobiotic toxicity testing and cell culture.
Particular areas of interest are the development of new analytical techniques and methods. These include 'smart wound dressings' for the diagnosis of wound infections, new electrochemical sensing systems for the detection of biological threats (healthcare and military), and developing novel ELISA methods for macromolecule detection - from food adulteration to forensic use through the speciation of blood found at crime scenes.
Research performed under this theme also includes a wide variety of microbiology-based research: identifying novel natural antimicrobials to combat skin infections, studying food contamination and water purification methods, and evaluating the toxicity of xenobiotics and their effects on mitochondria and oxidative stress using human cell culture.
A majority of the research is performed in our newly open state-of-the-art Biomedical Sciences Laboratories using a wide range of equipment for biochemical and electrochemical analyses, a range of microbiology equipment, in-house sensor printing and Atomic Force Microscopy.
- Hurley, I. P., Cook, R., Laughton, C. W., Pickles, N. A., Ireland, H. E., & Williams, J. H. H. (2009). Detection of human blood by immunoassay for applications in forensic analysis. Forensic Science International, 190, 91-97.
- Paterson, A. W. J., Curtis, J. C., & MacLeod, N. K. (2008). Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria. Journal of Neurochemistry, 105, 177-191.
- Pritchard, M., Craven, T., Mkandawire, T., Edmondson, A. S., & O'Neill, J. G. (2010). A study of the parameters affecting the effectiveness of Moringa oleifera in drinking water purification. Physics and Chemistry of the Earth, 35, 791-797.
- Sharp, D., Gladstone, P., Smith, R. B., Forsythe, S., & Davis, J. (2010). Approaching intelligent infection diagnostics: Carbon fibre sensor for electrochemical pyocyanin detection. Bioelectrochemistry., 77, 114-119.
Exemplar Areas For Degree Supervision
- Development of electroanalytical technologies for healthcare & military applications (e.g. wound monitoring, salivary markers of disease and non-invasive technologies)
- Developing colour-changing and antimicrobial delivery wound dressings
- The use of ELISA for macromolecular speciation (e.g. proteins, immunoglobulins)
- Studies into the efficacy of antimicrobials and antibiotic treatments
- Microbiological testing of water purification techniques and food contamination
- Toxicity and oxidative effects of xenobiotics on human cell culture