Centre for Biomedical Science Research
Centre for Biomedical Science Research
The Centre for Biomedical Science Research (CBSR) brings together a diverse group of biomedical researchers working in areas relating to human disease and wellbeing.
The aim of the Centre is to carry out high-quality and rigorous research that significantly adds new knowledge and advances tin this area. In addition to fundamental and basic science, we carry out applied research, which we aim to contribute to finding solutions to some of the key issues currently facing humankind.
Expertise within the group covers a broad range of disciplines including: molecular biology, cell biology, yeast genetics and fungal biology, biochemistry and biophysics, Electrochemistry, Nanotechnology, virology, microbiology and antimicrobials, DNA repair, platelet biology, neurodegenerative diseases and cell signalling. Principal investigators (PI) in the CBSR have well-established successful collaborations with excellent research groups based in Brazil, China, India, Ireland, France, Germany, Italy, Spain and the USA, in addition to many UK-based collaborations. In recent years members of the CBSR have published their work in leading scientific journals such as Cell, PNAS, Plant Cell, Nature Protocols, JACS, JBC, NAR PLOS Pathogens, PLOS Computational Biology, PLOS Genetics, Genome Research, Biosensors and Bioelectronics, amongst others.
Phone: +44 (0)113 812 23764
Our Research Facilities
In recent years Leeds Beckett University has invested close to £1 million in new resources for biomedical science research. This includes a newly refurbished biomedical research laboratory, which is stocked with state-of-the-art biochemical and cell biology equipment. Our facilities include hi-tech AKTA protein purifier, Seahorse Metabolic Analyser, FACS, RT-PCR, microbial fermenter, Nanosight particle analyser, advanced plate-readers, amongst other available resources. Our biomedical laboratory facilities allow us out carry out advanced microbiology, biochemistry and cell biology research that can produce high-impact publications.
Key Research Outputs
- Dr. John George: 2016 publication in Proceedings of the National Academy of Sciences USA: Significant discovery for antimicrobial resistance, showing crosstalk between two key pathways important for constructing the outer membrane of gram -ve bacteria.
- Dr. Vincent Postis: 2016 publication in Nature Protocols: Significant advancement in the purification procedure of membrane proteins. These proteins are notoriously difficult to purify, this new method provides a way of purifying within a lipid environment using SMALPs.
- Dr. Carine De Marcos Lousa: 2016 publication in Journal of Experimental Botany: Significant finding regarding first characterisation of non-SNARE proteins called phytolongins with respect to their sub-cellular localization and intracellular trafficking.
- Dr. Wayne Roberts: 2018 publication in BBA- Molecular Basis of Disease: Significant finding regarding the mechanism underlying how platelet derived microparticles induce angiogenesis. Identified miRNA Let-7a as a key player.
- Dr. Duncan Sharp and Dr. Andrew Paterson: 2018 publication in Biosensors and Bioelectronics: Significant advancement in electrochemistry through the improved design of carbon printed electrodes in determining and accurately measuring pH in complex culture media.
- Professor Gary Jones: 2018 publication in Cellular and Molecular Life Sciences: Significant advancement in our understanding of how the Hsp70 protein coordinates communication across its peptide-binding domain to facilitate structural and functional change.
PhD and Researcher Opportunities
If you’re interested in possibly pursuing a PhD within the CBSR or are looking for sponsorship for a personal scholarship or research fellowship, we are always looking for potential opportunities. In the first instance contact should be made with a potential PI that you want to work with. Following initial contact with a PI, further discussions will occur regarding possible funding options. Please note, the CBSR and School of Clinical and Applied Sciences, does not routinely have funding for PhD studies. When we do, these will be advertised in appropriate places. We do welcome enquiries from students who may potentially self-fund their PhD studies.
Members of the CBSR and Areas of Research Interest
Professor Gary Jones (Director)- protein chaperones, Hsp70, yeast, fungi, mycotoxins, antimicrobial resistance, cellular stress responses.
Dr. Duncan Sharp (Dean of School)- electrochemistry, electrode/sensor fabrication, point of care testing, minimally/ non-invasive diagnostics.
Dr. Carine De Marcos Lousa (Reader)- Nanomedicine, intracellular trafficking, plant, yeast.
Dr. Vincent Postis (Reader)- structural biology, X-ray crystallography, cryo-EM, ABC transporters, membrane proteins.
Dr. John George (Reader)- antimicrobial resistance, computational modelling, LPS, peptidoglycan synthesis.
Dr. Wayne Roberts (Course Director)- platelets, miRNA, angiogenesis, diabetes, cancer.
Dr. Donna Johnson (Course Director)- miRNAs, microbial pathogenesis, biomarkers of infectious disease.
Dr. Nat Milton (Principal Lecturer)- neurodegenerative diseases, Alzheimer’s disease, cannabinoids, aptamers, Kisspeptin, Kissorphin.
Dr. Sareen Galbraith (Senior Lecturer)- zoonotic viruses, hantaviruses, flaviviruses, RNA viruses, autophagy.
Dr. Sue Lang (Senior Lecturer)- MRSA, antimicrobial resistance, biofilm formation, virulence determinants.
Dr. Andrew Paterson (Senior Lecturer)- cell signalling, neurological diseases, nanoparticles, aptamers, cancer.
Dr. Tara Sabir (Senior Lecturer)- single molecule fluorescence, nanotechnology, fluorescence correlation spectroscopy.
Dr. Margaita Gomez-Escalada (Senior Lecturer)- antimicrobial resistance, natural products, propolis, antiseptics, disinfectants.
Dr. Steve Martin (Senior Lecturer)
Helen Battersby (PT Lecturer and PhD student)
Alex Liversidge (PT Lecturer and PhD student)- platelet transfusions, cryopreservation, transgender and non-binary community and impact on blood components.
Dr. Ian Hurley (Senior Lecturer)- development of biomolecular speciation assays.
Dr. Steve Atkinson(Senior Lecturer)