About Dr Alison Caswell
Dr Alison Caswell is a Principal Lecturer with a background in biochemistry. Alison's teaching involves the application of biochemistry to areas such as nutrition. She leads the Safety and Environmental Health Team.
Alison's role is primarily a combination of teaching and management activities. Her teaching interests have become quite diverse over the last few years although all tend to involve a measure of biochemistry, e.g. in relation to disease processes or the role of nutrition in the prevention of disease. She has also developed an interest in epidemiology, especially its application to the study of nutrition, and how this information complements evidence from laboratory studies.
She manages the Public Health Safety and Environment Team whose work includes undergraduate and postgraduate courses in Environmental Health, Health and Safety and Acoustics. There is also significant CPD and consultancy activity in the acoustics area and the team are looking to develop CPD and consultancy in other areas such as Health and Safety and Food Safety.
Furthermore she has been involved in various health and safety roles throughout her working life, and has been the Faculty coordinator since 2004 and chairs the Faculty Safety Health and Wellbeing Advisory Group.
Current Teaching
- BSc (Hons) Environmental Health Studies - Anatomy Physiology and Pathology Tutor
- BSc (Hons) Environmental Health Studies - Fundamentals of Science Tutor
- BSc (Hons) Nutrition - Nutrition and Food Sciences Module Tutor
- BSc (Hons) Nutrition - Clinical Nutrition Tutor
- BSc (Hons) Dietetics - Lifestyle Chronic Conditions Tutor
- BSc (Hons) Biomedical Sciences (All routes) - Understanding Disease Tutor
- BSc (Hons) Biomedical Sciences Human Biology and Physiology / Pharmacology routes - Human Lifespan Tutor
- BSc (Hons) Biomedical Sciences Human Biology route - Human Nutrition and Health Tutor
Research Interests
Dr Caswell has completed a term as a University Teacher Fellow and has specific interests in the use of e-portfolios and tools to help students visualise biomolecules.
Historic research activity includes cartilage and bone metabolism which is relevant to both arthritis and bone diseases such as osteoporosis.
Selected Publications
Journal articles (8)
- Caswell AM; West J (2002), An investigation into the factors affecting patient selection of chronic low back management methods, with particular reference to non-utilization of the complimentary therapies, in the United Kingdom. Journal of Back and Musculoskeletal Rehabilitation, vol. 16 (4), p. 121-133.
https://doi.org/10.3233/BMR-2002-16402 - Shafique M; Caswell AM (2001), Evidence that P1-purinoceptors of the A1-and A2-subclassas mediate opposing effects on the proliferation of MG-63 cells. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 16 (6), p. 1187-1187.
- Brown CJ; Caswell AM; Rahman S; Russell RGG; Buttle DJ (1997), Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1362 (2-3), p. 208-220.
https://doi.org/10.1016/S0925-4439(97)00080-X - Caswell AM; Mohiti J; Walker JH (1997), Nuclear annexin V expression and bone cell proliferation. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 25 (4), p. S582-S582.
- Mohiti J; Caswell AM; Walker JH (1997), The nuclear location of annexin V in the human osteosarcoma cell line MG-63 depends on serum factors and tyrosine kinase signaling pathways. Experimental Cell Research, vol. 234 (1), p. 98-104.
https://doi.org/10.1006/excr.1997.3584 - Caswell AM; Mohiti J; Walker JH (1997), 34 Nuclear annexin v expression and bone cell proliferation. Biochemical Society Transactions, vol. 25 (4)
- Mohiti J; Walker JH; Caswell AM (1996), Serum-induced redistribution of annexin V into the nuclei in the human osteosarcoma cell line MG-63. FASEB Journal, vol. 10 (6)
- Mohiti J; Caswell AM; Walkert JH (1995), Calcium-induced relocation of annexins IV and v in the human osteosarcoma cell line MG-63. Molecular Membrane Biology, vol. 12 (4), p. 321-329.
https://doi.org/10.3109/09687689509072434
Conference proceedings (peer reviewed) (1)
- MOHITI J; WALKER JH; CASWELL AM (1995) STUDIES ON ANNEXINS IN PRIMARY CULTURES OF HUMAN OSTEOBLASTS AND IN THE HUMAN OSTEOSARCOMA CELL-LINE MG-63. In: . : , pp. S36-S36.
Show/hide all publications
Journal articles (19)
- Caswell AM; West J (2002), An investigation into the factors affecting patient selection of chronic low back management methods, with particular reference to non-utilization of the complimentary therapies, in the United Kingdom. Journal of Back and Musculoskeletal Rehabilitation, vol. 16 (4), p. 121-133.
https://doi.org/10.3233/BMR-2002-16402 - Shafique M; Caswell AM (2001), Evidence that P1-purinoceptors of the A1-and A2-subclassas mediate opposing effects on the proliferation of MG-63 cells. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 16 (6), p. 1187-1187.
- Brown CJ; Caswell AM; Rahman S; Russell RGG; Buttle DJ (1997), Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1362 (2-3), p. 208-220.
https://doi.org/10.1016/S0925-4439(97)00080-X - Caswell AM; Mohiti J; Walker JH (1997), Nuclear annexin V expression and bone cell proliferation. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 25 (4), p. S582-S582.
- Mohiti J; Caswell AM; Walker JH (1997), The nuclear location of annexin V in the human osteosarcoma cell line MG-63 depends on serum factors and tyrosine kinase signaling pathways. Experimental Cell Research, vol. 234 (1), p. 98-104.
https://doi.org/10.1006/excr.1997.3584 - Caswell AM; Mohiti J; Walker JH (1997), 34 Nuclear annexin v expression and bone cell proliferation. Biochemical Society Transactions, vol. 25 (4)
- Mohiti J; Walker JH; Caswell AM (1996), Serum-induced redistribution of annexin V into the nuclei in the human osteosarcoma cell line MG-63. FASEB Journal, vol. 10 (6)
- Mohiti J; Caswell AM; Walkert JH (1995), Calcium-induced relocation of annexins IV and v in the human osteosarcoma cell line MG-63. Molecular Membrane Biology, vol. 12 (4), p. 321-329.
https://doi.org/10.3109/09687689509072434 - Leong WS; Russell RGG; Caswell AM (1994), Stimulation of cartilage resorption by extracellular ATP acting at P2-purinoceptors. BBA - General Subjects, vol. 1201 (2), p. 298-304.
https://doi.org/10.1016/0304-4165(94)90054-X - Oyajobi BO; Russell RGG; Caswell AM (1994), Modulation of ecto‐nucleoside triphosphate pyrophosphatase activity of human osteoblast‐like bone cells by 1α,25‐dihydroxyvitamin D3, 24R, 25‐dihydroxyvitamin D3, parathyroid hormone, and dexamethasone. Journal of Bone and Mineral Research, vol. 9 (8), p. 1259-1266.
https://doi.org/10.1002/jbmr.5650090816 - Oyajobi BO; Caswell AM; Russell RGG (1994), Transforming growth factor β increases ecto‐nucleoside triphosphate pyrophosphatase activity of human bone‐derived cells. Journal of Bone and Mineral Research, vol. 9 (1), p. 99-109.
https://doi.org/10.1002/jbmr.5650090114 - Caswell AM; Leong WS; Russell RGG (1992), Interleukin-1β enhances the response of human articular chondrocytes to extracellular ATP. BBA - Molecular Cell Research, vol. 1137 (1), p. 52-58.
https://doi.org/10.1016/0167-4889(92)90099-W - Caswell AM; Leong WS; Russell RGG (1991), Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture. BBA - General Subjects, vol. 1074 (1), p. 151-158.
https://doi.org/10.1016/0304-4165(91)90054-K - Caswell AM; Whyte MP; Russell RGG (1991), Hypophosphatasia and the extracellular metabolism of inorganic pyrophosphate: Clinical and laboratory aspects. Critical Reviews in Clinical Laboratory Sciences, vol. 28 (3), p. 195-232.
https://doi.org/10.3109/10408369109106863 - Caswel AM; Russell RGG; Whyte MP (1989), Hypophosphatasia: Pediatric forms. Journal of Pediatric Endocrinology and Metabolism, vol. 3 (2), p. 73-92.
https://doi.org/10.1515/JPEM.1989.3.2.73 - Caswell AM; Russell RGG (1988), Evidence that ecto-nucleoside-triphosphate pyrophosphatase serves in the generation of extracellular inorganic pyrophosphate in human bone and articular cartilage. BBA - General Subjects, vol. 966 (3), p. 310-317.
https://doi.org/10.1016/0304-4165(88)90080-3 - Caswell AM; Yousuf Ali S; Russell RGG (1987), Nucleoside triphosphate pyrophosphatase of rabbit matrix vesicles, a mechanism for the generation of inorganic pyrophosphate in epiphyseal cartilage. BBA - General Subjects, vol. 924 (2), p. 276-283.
https://doi.org/10.1016/0304-4165(87)90023-7 - Russell RGG; Caswell AM; Hearn PR; Sharrard RM (1986), Calcium in mineralized tissues and pathological calcification. British Medical Bulletin, vol. 42 (4), p. 435-446.
- Caswell AM; Whyte MP; Russell RGG (1986), Normal activity of nucleoside triphosphate pyrophosphatase in alkaline phosphatase-deficient fibroblasts from patients with infantile hypophosphatasia. Journal of Clinical Endocrinology and Metabolism, vol. 63 (5), p. 1237-1241.
https://doi.org/10.1210/jcem-63-5-1237
Conference proceedings (peer reviewed) (1)
- MOHITI J; WALKER JH; CASWELL AM (1995) STUDIES ON ANNEXINS IN PRIMARY CULTURES OF HUMAN OSTEOBLASTS AND IN THE HUMAN OSTEOSARCOMA CELL-LINE MG-63. In: . : , pp. S36-S36.
