Research at Leeds Beckett
Dr Vincent Postis
About Dr Vincent Postis
Vincent trained as a biochemist, and has developed research interests with multidisciplinary approaches ranging from molecular biology to biophysics. Vincent’s research output on membrane protein study of biomedical relevance have been published in high-profile international peer reviewed journals. Over the past 15 years, Vincent has been focusing his research on functional and structural characterisation of membrane transporter from organisms ranging from bacteria to humans. He has had a major contribution in developing techniques to improve membrane protein production and crystallisation. During his PhD, Dr Postis' studies focused on the adenine nucleoside transporter (Ancp) in yeast.
In 2005 he joined the University of Leeds as a Post-doctoral Research Fellow within the Membrane Protein Structure initiative (MPSi). He greatly contributed to the success of this project by designing and implementing automated methods for the high throughput cloning, expression and characterisation of membrane proteins. These methods led to the successful 2D and 3D crystallisation of multiple membrane proteins.
In 2010, he studied a peroxisomal ABC transporter (CTS) in insect cells known to be responsible for X-linked adrenoleukodystrophy and helped understanding that CTS has an additional thioesterase activity which is coupled to substrate transport and ATPase activities.
Vincent teaches the following modules on our BSc Biomedical Sciences courses:
- Biochemistry and Molecular Biology
- Clinical Biochemistry
And the following modules on out MSc Toxicological Sciences, MSc Microbiology and Biotechnology, and MSc Applied Biomedical Sciences Research:
- Bioanalytical Techniques
- Research Project
Today, Vincent's research focuses on a wide range of transporters of biomedical interest but a main aim is the study of the structure/function relationship of nucleoside transporters. His interest is focused on nucleoside transport into cells.
Using a range of biophysical approaches, the research program that Vincent is involved in aims to understand the conformational changes undergone by the nucleoside transporters during substrate transport across the lipid membrane, i.e. to probe the dynamics of the proteins in addition to determining the static structures of individual conformations by X-ray and electron crystallography.