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Dr Sareen Galbraith

About Dr Sareen Galbraith

Sareen E Galbraith is a molecular virologist working on RNA viruses. Work in her lab focuses on the interaction of positive stranded RNA viruses (flavivirus and alphavirus) with their mammalian hosts and on detection of these viruses in their mammalian and vector hosts.

After her initial PhD studies, she carried out two Postdoctoral Research Fellowships where her work focused on elucidating virulence determinants in Semliki Forest virus to give greater understanding of the molecular pathogenesis of the virus and improve vector biosafety. She then created a replication competent attenuated Semliki Forest virus vector for use as a vaccine and as a gene therapy agent for cancer and neurological diseases. She worked to develop and patent the replicating Semliki Forest virus vector with patent agents and Technology Transfer Managers for Trinity College and University College Dublin.

At the University of Texas Medical Branch, her research investigated the molecular epidemiology of West Nile virus. The results from this work have been used to inform vaccine design.

Her flavivirus research expanded to involve sequencing and molecular phylogenetic analysis of Japanese encephalitis virus (JEV); discovering a new fourth genotype of the virus. Recent work in her lab has examined the effect of autophagy on flavivirus and alphavirus growth in cells of the central nervous system.

Current Teaching

Sareen is a Senior Lecturer in Biomedical Science, and currently teaches on the following BSc (Hons) modules: 

  • Microbial World
  • Introduction to Biomedical Science
  • Principals of Pharmacology
  • Infectious Disease
  • Global Topics in Infectious Diseases

She also teaches on the following Masters modules:

  • Contemporary Research in Biomedical Sciences
  • Bioanalytical Techniques

Research Interests

Sareen's current work involves detection of zoonotic viruses, for example rodent borne Hantaviruses and mosquito borne flaviviruses, at home and overseas.

A collaborative NIHR funded study with Public Health England has investigated Hantaviruses as a cause of acute kidney injury in the UK and isolated a new strain of Hantavirus (Humber) from a farm in Yorkshire and the Humber. This study has been used to inform clinical practice and diagnostic testing of at risk groups, such as farmers, rodent control workers and dock workers, who present with acute kidney injury. New guidelines have been produced to inform and educate pet rat owners.

A collaborative BBSRC funded study has investigated the vector competence of British mosquitoes for flaviviruses. Flaviviruses are emerging and UK temperatures are increasing due to global warming. This is a multidisciplinary study based at the Liverpool School of Tropical Medicine. One of very few UK Universities to have containment level 3 insect facilities.

The other area of her current work examines the effect of autophagy on flavivirus and alphavirus growth. Autophagy is a cellular response to starvation that provides a short term supply of amino acids by degrading proteins. Induction of autophagy has been shown to both inhibit and enhance the growth of RNA virus. This is vital work because there are no therapeutics for flavivirus infections, which are an increasing public health threat. This is a collaborative study with Prof Tom Wileman’s lab at the University of East Anglia to inform the development of therapeutics for flavivirus encephalitis.

Selected Publications

Journal articles (220)

Books (4)

  • Galbraith S; Nandi M (2012) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics): Preface. 7668 LNCS.
  • Galbraith S; Paterson K (2008) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics): Preface. 5209 LNCS.
  • Galbraith S (2007) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics: Preface. 4887 LNCS.
  • Holland KE; Galbraith SS; Drolet BA (2005) Neonatal Violaceous Skin Lesions: Expanding the Differential of the "Blueberry Muffin Baby". 21. Elsevier BV.

Conference contributions (1)

Conference proceedings (27)

  • Galbraith SD; Scott M (In press) Exponentiation in Pairing-Friendly Groups Using Homomorphisms. In: . : Springer Berlin Heidelberg, pp. 211-224.
  • Galbraith SD; Lin X; Mireles Morales DJ (In press) Pairings on Hyperelliptic Curves with a Real Model. In: . : Springer Berlin Heidelberg, pp. 265-281.
  • Galbraith SD; Verheul ER (In press) An Analysis of the Vector Decomposition Problem. In: . : Springer Berlin Heidelberg, pp. 308-327.
  • Galbraith SD; Hess F; Vercauteren F (In press) Hyperelliptic Pairings. In: . : Springer Berlin Heidelberg, pp. 108-131.
  • Chiu YE; Havens PL; Siegel DH; Ali O; Wang T; Holland KE; Galbraith SS; Lyon VB; Drolet BA (2013) Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity. In: . : Elsevier BV, pp. 40-46.
  • Galbraith SL (2013) Electromagnetic sensing for deterministic finishing gridded domes. In: SPIE Defense, Security, and Sensing . : SPIE, pp. .
  • Motyer AJ; Galbraith S; Wilson SR (2010) Model selection procedures for high dimensional genomic data. In: . : , pp. .
  • Galbraith SD; Ruprai RS (2010) Using Equivalence Classes to Accelerate Solving the Discrete Logarithm Problem in a Short Interval. In: . : Springer Berlin Heidelberg, pp. 368-383.
  • Ivosevic M; Coguill SL; Galbraith SL (2009) Polymer thermal spraying: A novel coating process. In: . : , pp. 1078-1083.
  • Galbraith SD; Lin X; Scott M (2009) Endomorphisms for Faster Elliptic Curve Cryptography on a Large Class of Curves. In: . : Springer Berlin Heidelberg, pp. 518-535.
  • Galbraith S; Ruprai RS (2009) An Improvement to the Gaudry-Schost Algorithm for Multidimensional Discrete Logarithm Problems. In: . : Springer Berlin Heidelberg, pp. 368-382.
  • Galbraith SD; Harrison M; Mireles Morales DJ (2008) Efficient Hyperelliptic Arithmetic Using Balanced Representation for Divisors. In: . : Springer Berlin Heidelberg, pp. 342-356.
  • Benits WD; Galbraith SD (2008) The GPS Identification Scheme Using Frobenius Expansions. In: . : Springer Berlin Heidelberg, pp. 13-27.
  • Benits WD; Galbraith SD (2007) Constructing pairing-friendly elliptic curves using Gröbner basis reduction. In: . : , pp. 336-345.
  • Dent AW; Galbraith SD (2006) Hidden Pairings and Trapdoor DDH Groups. In: . : Springer Berlin Heidelberg, pp. 436-451.
  • Lucky AW; Prendiville JS; Galbraith SS; King DM; Drolet BA; Esterly NB (2006) Large Plantar Mass in a Newborn. In: . : Wiley, pp. 84-86.
  • Tran LM; Galbraith SJ; Liao JC (2005) Generalization of network component analysis. In: . : , pp. 9298.
  • Quinn K; Sheahan B; Galbraith S; Atkins G (2005) The treatment of experimental autoimmune encephalomyelitis using Semliki forest virus vectors expressing interferon beta. In: . : , pp. S48-S48.
  • Galbraith SD; Heneghan C; McKee JF (2005) Tunable Balancing of RSA. In: . : Springer Berlin Heidelberg, pp. 280-292.
  • Galbraith SD; McKee JF (2005) Pairings on Elliptic Curves over Finite Commutative Rings. In: . : Springer Berlin Heidelberg, pp. 392-409.
  • Galbraith SG; Henderson DK; Miller HA; Plieger PG; Tasker PA; Smith KJ; West LC (2003) Development of extractants to transport metal salts in base metal recovery processes. In: . : , pp. 941-954.
  • Galbraith SD (2003) Weil descent of Jacobians. In: . : Elsevier BV, pp. 165-180.
  • Lucky EAW; Prendiville JS; Galbraith SS; Fairley JA; Esterly NB (2002) White Papules in a Child with Down Syndrome. In: . : Wiley, pp. 271-273.
  • Noo F; Defrise M; Clack R; Roney TJ; White TA; Galbraith SG (1996) Stable and efficient shift-variant algorithm for circle-plus-lines orbits in cone-beam C.T.. In: . : , pp. 539-542.
  • Batchman TE; Mears CL; Galbraith SD; Taylor JP (1983) COMPUTER AIDED INSTRUCTION OF EM FIELD AND MICROWAVE COURSES.. In: . : , pp. 105-108.

Reports (1)

  • Galbraith SD; Paulus S; Smart NP (1998) Arithmetic on superelliptic curves.
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