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Dr Tara Sabir

About Dr Tara Sabir

Dr Tara Sabir is a Senior Lecturer teaching Biochemistry on the Biomedical Sciences BSc course in the Faculty of Health & Social Sciences. She has a background in biochemistry and biophysics specifically in the field of single molecule fluorescence nanotechnology.

Following on from her PhD Tara spent a number of years working for small commercial spin-off companies offering DNA/RNA and protein characterisation services to industry before returning to academia as a postdoctoral research associate at the Photon Science Institute, University of Manchester. During her postdoctoral research she used multi-parameter fluorescence detection (MFD) microscopy at the single molecule level to investigate the 3-D global structure of 4-stranded fork structures (4-SF) of E.coli. Following on from this research she was awarded a 6 month contract in collaboration with BP (British Petroleum) investigating novel single molecule nanotechnology applications to the oil industry.

Current Teaching

  • L4 Biochemistry
  • L4 Introduction to Biomedical Sciences
  • L5 Professional Scientific Practices
  • L6 Clinical Biochemistry

Research Interests

Tara's current research themes are focused in single molecule fluorescence nanotechnology and specifically novel instrumentation builds to investigate 3D structure, kinetics and dynamics of DNA/RNA and proteins.

Current projects in collaboration with Leeds University include the adaptation of an FCS (fluorescence correlation spectroscopy) instrument setup to full multi parameter fluorescence detection to include TCSPC (time correlated single photon counting) and PiE (pulsed interweaved excitation).

  • PhD student Mr Joel Crossley:
    FCS modification/ multiparameter fluorescence detection instrument build/ investigation of 3D structure of RNA stem loops of the Dengue Virus SLA
  • MSc student Mr Rui Taveres:
    Software design and comparison, CNS versus HandyFRET. Manipulation of single molecule ratiometric method of analysis for distance measurements

Selected Publications

Journal articles (4)

  • Sabir T; Sabir T (2012) Branchpoint expansion in a fully complementary three-way DNA junction
  • Sabir T; Toulmin A; Ma L; Jones AC; McGlynn P; Schröder GF; Magennis SW (2012) Branchpoint expansion in a fully complementary three-way DNA junction.
  • Sabir T; Schröder GF; Toulmin A; McGlynn P; Magennis SW (2011) Global structure of forked DNA in solution revealed by high-resolution single-molecule FRET.
  • Sabir T (2010) Single-Molecule Fluorescence Resonance Energy Transfer Assays Reveal Heterogeneous Folding Ensembles in a Simple RNA Stem-Loop
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