Dr Andrew Paterson
From a background in physiology and pharmacology, Andrew undertook a PhD examining mitochondria in models of disease. He is particularly interested in neurophysiology and neuropharmacology and has published a number of research articles within the field.
Andrew studied for a BSc (hons) Biomedical Sciences (Pharmacology) at Aberdeen University before moving to The University of Edinburgh to undertake a PhD looking at mitochondrial status in disease models within the neurodegeneration group in the Centre for Integrative Physiology.
Andrew has worked at Leeds Beckett University for a number of years teaching across physiology and pharmacology modules within the biomedical sciences undergraduate and postgraduate courses, and other professional courses. He has been on the supervisory team of a number of PhD students working within his areas of research interest.
- BSc (Hons) Biomedical Sciences: Human Physiology (1st Year), Medical Pathophysiology (2nd year), Topics in Neuroscience (3rd Year), Project (3rd Year)
- Biomedical Sciences MSc courses: Molecular Cell Biology and Physiology, Project
- BSc (Hons) Speech and Language Therapy: Medical Science 1, Medical Science 2
- BSc (hons) Nursing: Introduction to non-medical prescribing
Andrew uses a range cell culture approaches to investigate the effects of endogenous molecules and xenobiotics on cultured cells in vitro. Areas of current interest include:
- Studying the role of the formyl peptide receptors (FPRs) in the nervous system, where recent work has uncovered some intruiging roles for these receptors. Further exploration of these effects may suggest novel avenues of treatment of conditions ranging from neurodegenerative diseases, neurological cancers to neuropathic pain.
- The investigation of the cytotoxic properties of nanoparticles and their anti-cancer potential. This work involves the development and assessment of targetting ligands including antibodies and aptamers to direct nanoparticles towards cancerous cells, and could potentially be used to improve cancer diagnosis and treatment.
- The assessment of the cytotoxicity of herbal preparations and phytochemicals which show promise as novel antimicrobials, in collaboration with Dr Margarita Gomez Escalada. This work can be used to indicate the potential of such agents in the treatment of infections and as such can be used to help direct future research effort in combating infectious diseases and antibiotic resistance.
Ask Me About
- Biomedical Sciences
- Speech and Language Therapy
McBeth C; Paterson A; Sharp D (2020) Pad-printed Prussian blue doped carbon ink for real-time peroxide sensing in cell culture. Journal of Electroanalytical Chemistry, 878 pp. 114537-114537.
Paterson AWJ; Cussell PJG; Gomez Escalada M; Milton NGN (2020) The N-formyl peptide receptors : contemporary roles in neuronal function and dysfunction. Neural Regeneration Research, 15 (7), pp. 1191-1198.
Cussell PJG; Howe MS; Illingworth TA; Gomez Escalada M; Milton NGN; Paterson AWJ (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One, 14 (6),
Sharp DG; Paterson A; Mcbeth C; Al Dughaishi R (2018) Ubiquinone modified printed carbon electrodes for cell culture pH monitoring. Biosensors and Bioelectronics, 113 pp. 46-51.
Sibanda S; Akeel A; Martin SW; Paterson AW; Edge R; Al-Assaf S; Parsons BJ (2013) Efficiencies of fragmentation of glycosaminoglycan chloramides of the extracellular matrix by oxidizing and reducing radicals: potential site-specific targets in inflammation?. Free Radical Biology and Medicine, 65 pp. 280-290.
Sibanda S; Parsons BJ; Houee-Levin C; Marignier JL; Paterson AW; Heyes DJ (2013) One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study. Free Radical Biology and Medicine, 63 pp. 126-134.
Parsons BJ; Sibanda S; Heyes DJ; Paterson AW (2013) Reaction of superoxide radicals with glycosaminoglycan chloramides: a kinetic study. Free Radical Biology and Medicine, 61C pp. 111-118.
Akeel A; Sibanda S; Martin SW; Paterson AW; Parsons BJ (2013) Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. Free Radical Biology and Medicine, 56 pp. 72-88.
Paterson AWJ; Curtis JC; MacLeod NK (2008) Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria. Journal of Neurochemistry, 105 (1), pp. 177-191.
Kriaucionis S; Paterson A; Curtis J; Guy J; MacLeod N; Bird A (2006) Gene Expression Analysis Exposes Mitochondrial Abnormalities in a Mouse Model of Rett Syndrome. Molecular and Cellular Biology, 26 (13), pp. 5033-5042.